Research Article
Open Access
Prediction of Antihypertensive Activity of 1-Alkyl-N-[(1R)-1 (fluorophenyl)-2-methylpropyl]Piperidine-4-Carboxamide Derivatives
Shailja Sachan1*, Amitabh Tripathi2, Pradeep Chandra Shukla3 , B K Gupta4
1Department of Chemistry, Govt. MSG College,Rewa, M.P. India,
2Department Of Chemistry, AwadheshPratap Singh University, Rewa, M.P. India,
3Department Of Chemistry, Y.P.S. College, Sirmour, Rewa,M.P., India 4Department of chemistryGovt. P G College Satna M.P. India
Shailja Sachan et al /Int.J. TechnoChem Res. 2015,1(2),pp 79-85.
Abstract
We have studied a series of 1-Alkyl-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]
piperidine-4-carboxamide Derivatives as Novel Antihypertensive Agents by incorporating QSAR
methodology. We found that parameters EtaBetaS (Extended Topochemical Atom Index sigma VEM
count), EtaLA (Eta average local composite index) , PVSAp1 (P van der Waals surface area-like index
on Polarizability) SMTI (Schultz Molecular Topological Index) are very closely related with
antihypertensive activity of these derivatives.
Keywords
Antihypertensive Activity, 1-Alkyl-N-[(1R)-1-(fluorophenyl)-2-methylpropyl]Piperidine 4-Carboxamide, Derivatives.