S.P.Deshmukh, Dr. N.S.Bhajipale, V.M.Vaidya, A.G.Sinhe

ABSTRACT

TDDS are topically administration of medicaments through the skin for systemic effects at a predetermined and controlled rate in the form of transdermal patches. Transdermal drug delivery of antihypertensive drugs is able to provide optimum amount of drug to control the disease condition along with minimum side effects. The TDDS avoidance of first pass metabolism and other variables associated with the GI tract, such as Hypertension is directly responsible for 57% of all stroke deaths and 24% of all coronary heart disease deaths in India. Oral drug administration is limited by many disadvantages. This review on different antihypertensive drugs showed that, by delivering drug through this route improves bioavailability a well as patient compliance. This can also lead to cost effectiveness of healthcare treatment for the long term management of hypertension. But the main limitation is that, the drug should possess certain specific physicochemical properties which should be suited to permeate through the skin, therefore all antihypertensive drugs cannot be given by this route. Key words: Anithypertensive drug delivery, Transdermal patches.