Archana

ABSTRACT

A new series of thiazolidin-4-one derivatives were synthesised by reaction of 3-amino-2-methyl-6-monosubstituted quinazolin-4(3H)-ones (1a-1b) with various substituted aldehydes and thioglycolic acid in presence of acetic acid in toluene. The structures of these compounds have been established by elemental (C,H,N) and spectral (IR, H-NMR, and Mass) analysis. The synthesised compounds were screened in vivo ,for their acute toxicity and anticonvulsant activity in MES and PTZ models. Almost all compounds have shown promising anticonvulsant activity. Compound 3k was the most potent compound of this series. Key words : Quinazolinonyl-4-thiazolidinones, anticonvulsant activity, acute toxicity.