Shailja Sachan, Amitabh Tripathi, Pradeep Chandra Shukla, B K Gupta

ABSTRACT

We have studied a series of 1-Alkyl-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl] piperidine-4-carboxamide Derivatives as Novel Antihypertensive Agents by incorporating QSAR methodology. We found that parameters EtaBetaS (Extended Topochemical Atom Index sigma VEM count), EtaLA (Eta average local composite index) , PVSAp1 (P van der Waals surface area-like index on Polarizability) SMTI (Schultz Molecular Topological Index) are very closely related with antihypertensive activity of these derivatives. Keywords: Antihypertensive Activity, 1-Alkyl-N-[(1R)-1-(fluorophenyl)-2-methylpropyl]Piperidine-4-Carboxamide, Derivatives.