Steegers Theunissen*, Eaton Fitch

ABSTRACT

: Heterocyclic compounds containing sulfur and nitrogen are pivotal in the development of both synthetic and pharmaceutical chemistry. Thiazoles, in particular, serve as essential building blocks for the construction of biologically active scaffolds such as 4-thiazolidinones and benzothiazoles. These molecules are integral to a range of medicinal agents, including vitamin B analogues, sulfonamide derivatives, promizole, niridazole, aminotriazole, and tetramisole, highlighting their pharmacological significance. Despite their widespread use, a comprehensive understanding of the reaction pathways and kinetic profiles of thiazole transformations remains limited. This work investigates the interaction of thiazole with sodium methoxide under continuous stirred tank conditions, focusing on unraveling the sequence of mechanistic steps, identifying rate-determining events, and mapping dynamic reaction behaviors. By elucidating these kinetic and mechanistic aspects, the study aims to facilitate the rational design of thiazole-based syntheses and optimize reaction efficiency for pharmaceutical and industrial applications. Keywords:Thiazole chemistry; Reaction pathway analysis; Sodium methoxide interaction; Continuous stirred tank methodology; Mechanistic investigation.