International Journal of
TechnoChem Research

ISSN 2395 - 4248

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NEWS & UPDATION

  • 2017, Volume 3 No 3 of International Journal of TechnoChem Research is released.
  • 2017, Volume 3 No 3 of International Journal of TechnoChem Research is released.

    2017, Volume 3, No 3, of International Journal of TechnoChem Research is released

  • Included in CAS Database, USA [by Chemical Abstracts Service, USA]
  •  International  Journal of TechnoChem Research

    has been selected for inclusion in CAS,USA  by  Chemical Abstracts Service, USA.

  • International Journal of TechnoChem Research
  • International Journal of TechnoChem Research has been selected for inclusion in CAS,USA by Chemical Abstracts Service, USA.

    International Journal of TechnoChem Research has been selected for inclusion in CAS,USA by Chemical Abstracts Service, USA.

ABSTRACT

Synthesis and antimicrobial evaluation of newer 1,3,4-oxadiazole derivatives containing R-phenyl moiety under conventional conditions

Ashwini H. Pagare, Rani S. Kankate, Anwar R. Shaikh

ABSTRACT

A series of newer 1,3,4-oxadiazole derivatives containing R-phenyl moiety were synthesized by reacting R-substituted aromatic acids with hydrazine hydrate in presence of various reagents at different reaction conditions. The structural elucidation of these compounds is based on their spectral data (IR, 1HNMR,MS and elemental analysis).All the newly Synthesized 1,3,4-oxadiazole derivatives have been screened for their antibacterial activity against three different strains, namely E. coli, S. aureusand P. aeruginosa, while antifungal activity was determined against three different strains such asC.neoformans, C. albicans andC.glabrata. The investigation of antimicrobialscreening revealed that compounds 4a, 4g, and 4hexhibited excellent activity when compared with the standard drugs. Keywords: 1,3,4-oxadiazole derivatives containing R-phenyl moiety, Antibacterial activity, Antifungal activity, Characterization data, Conventional conditions.

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