International Journal of
TechnoChem Research

ISSN 2395 - 4248

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  • Co-Published with Asian Publication Corporation
  •  Co-Published with Asian    Publication Corporation  

     Co-Published with Asian    Publication Corporation  

     Co-Published with Asian    Publication Corporation  

     Co-Published with Asian    Publication Corporation  

ABSTRACT

Synthesis of Newer Substituted Azetidinone and Thiazolidinone derivatives as potent Anticonvulsant Agents

Archana

ABSTRACT

Various 2-N-(2-Phenyl -1H-indol-3yl)-imino benzene/thiophenol ( 3a – 3e) , 3-Chloro-1-(benzyl/thiophenyl)-4-(2-1H-indol-3yl) azetidin-2-ones (4a-4e) and 3-Substituted benzyl/thiophenyl -4-(2-phenyl 1H-indol-3-yl) thiazolidin-4-ones (5a-5e) have been synthesised . The structures of these compounds have been established by elemental (C,H,N) and spectral (IR, H-NMR, and Mass) analysis. The synthesised compounds were screened in vivo ,for their acute toxicity and anticonvulsant activity in MES and PTZ models. Almost all compounds have shown promising anticonvulsant activity. Compound 5d was the most potent compound of this series. Key words : Substituted Indolyl azetidinones, Substituted Indolyl thiazolidinones, anticonvulsant activity, acute toxicity.

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