International Journal of
TechnoChem Research

ISSN 2395 - 4248

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NEWS & UPDATION

  • 2017, Volume 3 No 3 of International Journal of TechnoChem Research is released.
  • 2017, Volume 3 No 3 of International Journal of TechnoChem Research is released.

    2017, Volume 3, No 3, of International Journal of TechnoChem Research is released

  • Included in CAS Database, USA [by Chemical Abstracts Service, USA]
  •  International  Journal of TechnoChem Research

    has been selected for inclusion in CAS,USA  by  Chemical Abstracts Service, USA.

  • International Journal of TechnoChem Research
  • International Journal of TechnoChem Research has been selected for inclusion in CAS,USA by Chemical Abstracts Service, USA.

    International Journal of TechnoChem Research has been selected for inclusion in CAS,USA by Chemical Abstracts Service, USA.

ABSTRACT

Synthesis and biological evaluation of some new 3-[2’-methyl-6’-monosubstituted quinazolinon-4’-(3’H)-onyl]-2-substituted aryl-4-thiazolidinones as anticonvulsant agents

Archana

ABSTRACT

A new series of thiazolidin-4-one derivatives were synthesised by reaction of 3-amino-2-methyl-6-monosubstituted quinazolin-4(3H)-ones (1a-1b) with various substituted aldehydes and thioglycolic acid in presence of acetic acid in toluene. The structures of these compounds have been established by elemental (C,H,N) and spectral (IR, H-NMR, and Mass) analysis. The synthesised compounds were screened in vivo ,for their acute toxicity and anticonvulsant activity in MES and PTZ models. Almost all compounds have shown promising anticonvulsant activity. Compound 3k was the most potent compound of this series. Key words : Quinazolinonyl-4-thiazolidinones, anticonvulsant activity, acute toxicity.

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