International Journal of
TechnoChem Research

ISSN 2395 - 4248

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NEWS & UPDATION

  • 2017, Volume 3 No 3 of International Journal of TechnoChem Research is released.
  • 2017, Volume 3 No 3 of International Journal of TechnoChem Research is released.

    2017, Volume 3, No 3, of International Journal of TechnoChem Research is released

  • Included in CAS Database, USA [by Chemical Abstracts Service, USA]
  •  International  Journal of TechnoChem Research

    has been selected for inclusion in CAS,USA  by  Chemical Abstracts Service, USA.

  • International Journal of TechnoChem Research
  • International Journal of TechnoChem Research has been selected for inclusion in CAS,USA by Chemical Abstracts Service, USA.

    International Journal of TechnoChem Research has been selected for inclusion in CAS,USA by Chemical Abstracts Service, USA.

ABSTRACT

Prediction of Antihypertensive Activity of 1-Alkyl-N-[(1R)-1-(fluorophenyl)-2-methylpropyl]Piperidine-4-Carboxamide Derivatives

Shailja Sachan, Amitabh Tripathi, Pradeep Chandra Shukla, B K Gupta

ABSTRACT

We have studied a series of 1-Alkyl-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl] piperidine-4-carboxamide Derivatives as Novel Antihypertensive Agents by incorporating QSAR methodology. We found that parameters EtaBetaS (Extended Topochemical Atom Index sigma VEM count), EtaLA (Eta average local composite index) , PVSAp1 (P van der Waals surface area-like index on Polarizability) SMTI (Schultz Molecular Topological Index) are very closely related with antihypertensive activity of these derivatives. Keywords: Antihypertensive Activity, 1-Alkyl-N-[(1R)-1-(fluorophenyl)-2-methylpropyl]Piperidine-4-Carboxamide, Derivatives.

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